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Updated: Jun 12, 2025

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

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鉴定与较低的艾滋病毒病毒载量和病毒性控制相关的抗体点

Wendy Grant-McAuley1, William R Morgenlander1,2, Ingo Ruczinski3

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

PloS one
|September 17, 2024
PubMed
概括

研究人员发现,特定的HIV抗体点与较低的病毒载量 (VL) 和HIV控制者状态有关. 整个HIV基因组的广泛抗体反应性也与未接受抗逆转录病毒疗法 (ART) 的人群中更好的病毒制相关.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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