使用阴离子交换树脂在木中丰富脱氧尼吉里米辛:吸附/脱附特性和过程优化
Jilong Ma1, Yiqian Ye1, Rushi He1
1Department of Chemical and Pharmaceutical Engineering, School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Food chemistry
|September 17, 2024
概括
这项研究开发了一种简单的阴离子交换树脂方法,以从木叶提取物中丰富脱氧尼吉米辛 (DNJ). 这一过程显著提高了DNJ的纯度和回收,使其在工业上可行.
科学领域:
- 生物化学 生物化学
- 自然产品化学 自然产品化学
- 分离科学 分离科学
背景情况:
- 脱氧尼吉米辛 (DNJ) 是一种有价值的α-葡萄糖酶抑制剂,在像Morus alba L.这样的植物中发现.
- 现有的DNJ缩方法复杂且昂贵,限制了其实际应用.
- 需要有效的提取和净化技术来利用DNJ的潜力.
研究的目的:
- 开发一种简单而高效的方法,从Morus alba L.提取物中致富脱氧尼吉米辛 (DNJ).
- 为了优化DNJ净化使用阴离子交换树脂.
- 评估拟议的缩工艺的工业可行性.
主要方法:
- 用于DNJ吸附和脱附的利用了离子交换树脂 (LSI和D113).
- 研究了吸附动力学 (伪第一阶) 和异温模型 (Langmuir).
- 优化的参数包括提取物度,pH值,溶解剂和色谱条件.
主要成果:
- 吸附遵循伪第一阶动力学和兰格穆尔等温法,表明化学吸收.
- 优化的阴子交换染色学实现了44.00%的DNJ纯度.
- 使用LSI-D113树脂组合,获得了高总回收率78.21%.
结论:
- 阴离子交换树脂色谱为DNJ丰富提供了一种简单,高效和工业上可行的方法.
- 该LSI-D113树脂策略有效地提高了DNJ纯度和从Morus alba L.提取物中回收.
- 这项研究为DNJ在食品和潜在的制药行业的更广泛应用铺平了道路.
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