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在乳腺癌中非编码RNA和雌激素受体信号传递:基于纳米技术的治疗方法

Amer Al Ali¹, Tareg M Belali², Mohammed H Abu-Alghayth²

¹Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Bisha, 255, Al Nakhil, Bisha 67714, Saudi Arabia.

Pathology, research and practice

|September 17, 2024

概括

本综述探讨了非编码RNAs (ncRNAs) 如何调节乳腺癌中的雌激素受体 (ER) 途径. 它强调了纳米技术.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
纳米技术纳米技术

背景情况:

乳腺癌是全球女性的主要癌症,雌激素受体 (ER) 信号在其进展中起着关键作用.
传统的乳腺癌治疗包括手术,化疗,放射治疗,向治疗和激素治疗.
纳米医学为乳腺癌治疗提供了一个有前途的途径,旨在改善向性治疗并减少与传统化疗相比的毒性.

研究的目的:

研究非编码RNAs (ncRNAs) 在乳腺癌内的ER信号通路中的调节作用.
探索纳米技术在通过有针对性的药物输送系统提高治疗疗效方面的潜力.
审查长非编码RNAs (lncRNAs) 和微RNAs (miRNAs) 与ER途径之间的相互作用及其对乳腺癌的影响.

主要方法:

来自知名科学数据库 (PubMed,Elsevier,Springer,Wiley,Taylor & Francis) 的研究的综合文献评论.
对乳腺癌中ER信号的非编码RNA调节现有研究的分析.
检查当前和新兴的纳米技术在癌症药物输送中的应用.

主要成果:

非编码RNAs,包括lncRNAs和miRNAs,与ER信号通路显著相互作用.
这些相互作用影响了乳腺癌的进展和治疗反应.
基于纳米技术的药物输送系统显示出有针对性输送,降低毒性和提高治疗疗效的潜力.

结论:

ncRNAs是乳腺癌中ER信号的关键调节者,提供潜在的治疗点.
纳米医学提供了一个有希望的策略,通过利用ncRNA-ER通路相互作用来克服传统乳腺癌治疗的局限性.
通过纳米载体的治疗剂的向输送可以改善ER阳性乳腺癌的治疗结果.

关键词:

乳腺癌乳腺癌乳腺癌这是一个LncRNARNA.纳米颗粒纳米颗粒这是一个小RNARNA.

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