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一个与年龄相关的毛 follicle 数的nomogram:一个观察研究3821妇女的观察研究
N Balachandren1, S L Kastora1, E Yasmin1
1Reproductive Medicine Unit, University College London Hospital, London, UK.
Reproductive biomedicine online
|September 17, 2024
概括
一个新的腹卵泡计数 (AFC) 诺莫图显示预期的AFC值根据年龄,有助于评估卵巢储备. 这种工具对于女性来说是有用的,不管她们的月经周期阶段或避孕药的使用.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇科超声波 妇科超声波
- 卵巢储备评估 卵巢储备评估
背景情况:
- 前毛囊数 (AFC) 是卵巢储备的一个关键指标.
- 了解AFC与时间年龄之间的关系对于准确的生育能力评估至关重要.
- 现有的AFC数据可能无法解释月经周期阶段或荷尔蒙避孕药使用的变化.
研究的目的:
- 为了建立一个基于时间年龄的综合性 antral 毛囊数 (AFC) nomogram.
- 为了确定预期的AFC值在整个生殖年,独立于月经周期阶段.
- 为接受卵巢储备评估的妇女提供可靠的咨询工具.
主要方法:
- 这是一项回顾性队列研究,涉及了来自7573名患者的8821个经阴道超声 (TVUS) 记录.
- 开发一个AFC名图来估计AFC百分位数 (第10,第25,第50,第75,第90) 的年龄.
- 在特定人群中AFC分布的分析,包括那些先前有卵巢囊切除术和荷尔蒙避孕的人群.
主要成果:
- 在名ogram人口中观察到AFC和年龄之间的高斯关系.
- 在21-23岁之间,AFC中位数达到30的峰值.
- 在曾经接受过卵巢囊切除术的妇女中,AFC分布有显著差异 (P < 0.0001),但在使用荷尔蒙避孕药的妇女中没有显著差异 (P = 0.43).
结论:
- 成功开发了一种提供按时间年龄分类的中位数和四分位数间值的AFC nomogram.
- 这个名图表作为一个有价值的辅导工具在卵巢储备评估.
- 阴影图适用于所有月经周期阶段以及使用荷尔蒙避孕药或有卵巢囊切除病史的女性.
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