多发性硬化症治疗不足预测多发性硬化症患者中阻塞性睡眠呼吸暂停的高风险
John Patrick Dempsey1, Alexandra Balshi2, Andrew Bouley3
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Multiple sclerosis and related disorders
|September 17, 2024
概括
多发性硬化症 (MS) 患者未充分利用疾病修饰疗法 (DMT) 并经历疲劳,患有阻塞性睡眠呼吸暂停 (OSA) 的风险更高. 积极的MS治疗可能会降低OSA风险.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在多发性硬化症 (MS) 患者中比一般人群更为普遍.
- 多发性硬化症治疗,疾病活动,严重程度,疲劳和OSA之间的联系仍然不清楚.
研究的目的:
- 调查OSA风险,MS疲劳和MS严重程度之间的关联.
- 在一般人群中控制已知的OSA风险因素.
主要方法:
- 给多发性硬化症患者的OSA和疲劳调查问卷.
- 收集的人口统计和临床数据.
- 使用多变量逻辑回归来分析OSA风险和MS疾病严重程度之间的关系.
主要成果:
- 在药物占有率 (MPR) 和高OSA风险之间发现了反向相关性.
- 疲劳和非白人种族与高OSA风险正相关.
- 对男性性别,年龄较小和BMI进行控制的模型.
结论:
- 疾病修饰疗法 (DMT) 的不足使用,疲劳和非白人种族预测MS患者的高OSA风险.
- 建议进行积极的MS治疗,以减轻并发性OSA和MS相关疲劳的风险.
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