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Updated: Jun 12, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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发现口服可生物利用的ALK PROTACs,基于对抗ALK阳性癌症的利尼布

Haoxuan Zhou1, Mingxing Hu1, Hui Jie2

  • 1Department of Nuclear Medicine and Clinical Nuclear Medicine Research Lab, West China Hospital, Sichuan University, Chengdu, 610041, China.

European journal of medicinal chemistry
|September 17, 2024
PubMed
概括

新的蛋白质溶解向嵌合体 (PROTAC) 分子向形淋巴瘤激酶 (ALK) 融合蛋白提供了一种有前途的策略,以克服ALK驱动癌症的耐药性. PROTAC 4B显示出强大而持久的ALK降解,在体外和体内表现出显著的抗增殖活性.

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