使用循环的无细胞DNA检测抗体-药物结合物诱导的间歇性肺病
A Grinshpun1, A Zick2, T Perri3
1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem; Hadassah Cancer Research Institute and Wohl Institute for Translational Medicine, Hadassah-Hebrew University Medical Center, Jerusalem; The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem.
ESMO open
|September 17, 2024
概括
监测与抗体-药物联合体 (ADC) 相关的间歇性肺病 (ILD) 是至关重要的. 血液中无细胞DNA (cfDNA) 的肺特异甲基化分析显示,对检测和监测ADC诱导的ILD有希望.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 分子诊断学 分子诊断学
背景情况:
- 抗体与药物合物 (ADC) 越来越多地使用,造成致命的药物诱导间歇性肺病 (ILD) 的风险.
- 早期识别和监测ILD在接受T-DXd等ADCs的患者中的ILD至关重要.
研究的目的:
- 调查循环无细胞DNA (cfDNA) 甲基化分析对于检测和监测T-DXd相关ILD的有用性.
- 确定cfDNA作为肺损伤潜在的非侵入性生物标志物.
主要方法:
- 对cfDNA进行了组织特异性甲基化分析,对来自T-DXd相关ILD患者的血液样本进行了分析.
- 分析包括在活跃的ILD,恢复和重新挑战期间采集的样本.
- 验证使用来自HER2阳性转移性乳腺癌患者队列的血样本进行,这些患者接受了T-DXd治疗.
主要成果:
- 在接受T-DXd治疗的患者中,肺衍生的cfDNA水平增加与活性ILD有关.
- 这一发现在患有HER2阳性转移性癌症的患者中观察到,与临床和CT扫描评估相关.
结论:
- 使用cfDNA甲基化分析的液体活检是检测和监测ADC相关ILD的一个可行的工具.
- 这种方法提供了一个潜在的低成本,简单的替代目前的成像模式,值得进一步的临床研究.
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