在怀孕期间测量阿司匹林反应的敏感客观标志物:一个探索性范围审查
Azhar Al-Khulaifi1, Malkan Khatib2, Gamal Sayed3
1Department of Obstetrics and Gynecology, Women Wellness and Research Center, Doha, Qatar; Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Journal of reproductive immunology
|September 17, 2024
概括
在怀孕期间使用阿司匹林预防妊娠前需要标准化剂量和验证的血清标志物,以确保怀孕期间的阿司匹林反应 (ARP). 需要进一步的研究来解决这些差距.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 阿司匹林在怀孕期间通常被处方以减轻子宫前风险.
- 它的机制涉及抑制血小板功能,但最佳使用是有争议的.
- 关于适当的阿司匹林剂量和可靠的标记物来评估怀孕中阿司匹林反应 (ARP) 存在不确定性.
研究的目的:
- 进行关于怀孕中阿司匹林反应 (ARP) 的文献综述.
- 确定有关ARP评估的知识差距.
- 调查评估ARP的客观生物标志物,考虑阿司匹林配方,剂量和患者并发症等因素.
主要方法:
- 在PubMed,SCOPUS和Cochrane数据库中进行了全面的文献搜索,截至2024年3月.
- 关键词包括"阿司匹林"",怀孕"和"反应能力".
- 纳入标准集中在18岁以上的孕妇,无论出于什么医疗原因都被处方阿司匹林.
主要成果:
- 不同的阿司匹林配方之间没有发现响应的显著差异.
- 报道了多种多样的阿司匹林剂量,表明需要标准化剂量协议和对更高剂量的调查.
- 关于ARP评估的生物标志物存在缺乏共识,医疗并发症被确定为不响应的预后因素.
结论:
- 关于ARP,仍然存在很大的不确定性.
- 关键的缺陷包括血清标志物的验证,了解并发症对ARP的影响,以及在怀孕期间建立适当的阿司匹林剂量策略.
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