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在接受氧化治疗的患者中,微血管密度的眼间不对称性通过光学连贯性断层扫描血管造影
Huangdong Li1, Jingyu Zhang1, Xi Yin1
1Ophthalmic Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China.
Microvascular research
|September 17, 2024
概括
在SLE患者中,氧化 (HCQ) 治疗导致明显的眼间视网膜微血管密度不对称. 这种不对称性可以帮助选HCQ诱导的视网膜毒性.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 氧化 (HCQ) 是一种常见的系统性红斑狼 (SLE) 治疗方法.
- HCQ可能会引起视网膜毒性,需要监测.
- 评估视网膜微血管结构的眼间差异可能会揭示早期毒性迹象.
研究的目的:
- 为了研究用HCQ治疗的患者眼睛之间的视网膜微血管密度不对称.
- 为了确定这种眼间不对称性是否在HCQ治疗的SLE患者和正常对照人之间有所不同.
- 评估眼间不对称的潜力作为HCQ视网膜病变的生物标志物.
主要方法:
- 对20名SLE患者进行HCQ和20名年龄/性别匹配的正常对照 (NC) 的横截面研究.
- 光学连贯断层扫描血管造影 (OCTA) 用于测量黄斑和周围毛囊微血管和微结构参数.
- 由右眼和左眼测量之间的绝对差异量化的眼睛间不对称性.
主要成果:
- 与NCs相比,HCQ的患者在两只眼睛中显示出斑点和周围斑点血管密度降低.
- 在HCQ组中观察到表面毛细管 (SCP) 的黄斑整体图像血管密度 (wiVD-M) 和周周血管密度 (pfVD) 中明显较高的眼间不对称.
- wiVD-M和pfVD的眼间不对称性证明了用于识别HCQ治疗效应的良好的区分能力.
结论:
- 系统性红斑狼患者在HCQ上表现出较大的眼睛间视网膜微血管密度不对称.
- 间眼血管密度不对称是检测HCQ诱导的视网膜毒性的一种潜在查工具.
- 进一步的研究可以探索这种不对称性在常规监测中的临床实用性.
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