炎症因子TNFα诱导的circDMD调解R环形成,促进瘤发生
Qi Sun1, Zhen Yang2, Minghan Qiu3
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; Tianjin Institutes of Health Science, Tianjin 301600, China; Tianjin Cancer Institute of Integrative Traditional Chinese and Western Medicine, Tianjin Union Medical Center of Nankai University, Tianjin 300121, China.
慢性炎症可以促进癌症. 这项研究表明,由TNFα诱导的循环RNAcircDMD通过激活NF-κB信号和促进瘤生长和转移来驱动子宫癌.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 慢性炎症与癌症的发展有关.
- 循环RNAs (circRNAs) 在炎症驱动的瘤发生中的作用尚未完全理解.
- 研究炎症因素和circRNAs之间的相互作用对于了解癌症进展至关重要.
研究的目的:
- 为了阐明circDMD在TNFα诱导的宫癌中的作用.
- 确定circDMD对瘤发生有所贡献的分子机制.
- 探索circDMD作为宫癌的潜在治疗点.
主要方法:
- 利用TNFα诱导的HeLa细胞模型和体内瘤模型.
- 使用定量PCR研究circRNA表达.
- 分析了蛋白质-蛋白质相互作用和基因表达水平.
- 进行功能测试以评估瘤扩散,转移和自.
主要成果:
- 在TNFα诱导的HeLa细胞中,circDMD的表达被上调.
- circDMD促进了核因子kappa B (NF-κB) 的激活和核转移.
- circDMD海绵化miR-4711-5p,导致氨酸脱甲基酶5A (KDM5A) 的增加和细胞因子信号传递抑制剂1 (SOCS1) 的降低.
- 通过R循环形成,circDMD增强了Rela原型瘤基因 (P65) 表达和Fms相关受体氨酸激酶4 (VEGFR3) 表达.
- 在体外和体内,circDMD促进了瘤扩散,转移和自.
结论:
- circDMD是由TNFα诱导的,并促进子宫癌的进展.
- circDMD作为miR-4711-5p的分子海绵,影响KDM5A和SOCS1水平.
- circDMD激活NF-κB信号,驱动瘤生长,转移和自.
- circDMD代表了宫癌的潜在治疗标.
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