维生素D作为参与心血管疾病的分子通路调节器:临床前研究的证据
Athira Anilkumar S1, Soumam Dutta1, Shabna Aboo1
1Department of Endocrinology, ICMR-National Institute of Nutrition, Hyderabad, India.
Life sciences
|September 17, 2024
概括
维生素D缺乏与心血管疾病有关. 临床前研究表明,维生素D通过减少炎症和改善功能来保护心脏和血管,这表明其具有治疗潜力.
科学领域:
- 心血管研究研究心血管研究
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 维生素D缺乏症 (VDD) 影响全球近10亿人.
- 越来越多的证据将VDD与心血管疾病 (CVD) 风险增加联系在一起,包括高血压,动脉样硬化和心力衰竭.
- 维生素D的受体和代谢酶存在于心脏和血管细胞中,表明它在心血管健康中发挥着直接作用.
研究的目的:
- 综合和批判地评估关于维生素D在心血管健康中的作用的临床前证据.
- 了解维生素D影响心血管功能的分子机制.
- 评估维生素D作为心血管疾病预防或治疗策略的潜力.
主要方法:
- 综述了各种临床前研究,包括体外 (心肌细胞细胞系) 和体内模型 (淘汰赛小鼠,饮食引起的缺乏症,疾病特异性的动物模型).
- 对研究维生素D对信号传导通路 (例如NF-kB,Nrf2,PI3K/AKT/mTOR) 和表观遗传机制的影响的研究分析.
- 在各种心血管疾病模型中评估维生素D补充效应.
主要成果:
- 维生素D调节血管律,通过多种信号通路预防心脏纤维化和过度缩小.
- 实验室研究表明,维生素D促进心肌细胞分化,并抑制病理重塑.
- 在体内研究表明,VDD对心脏有有害的影响,而维生素D补充剂可以防止炎症,增大,斑块形成,并在心血管疾病模型中改善心脏功能.
结论:
- 临床前证据强烈支持维生素D在维持心血管健康方面发挥关键作用.
- 维生素D在实验模型中显示出对各种心血管病理的显著保护作用.
- 需要进一步的研究来协调临床前发现与临床结果,并确定维生素D在心血管疾病中的治疗应用.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
2.1K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.1K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:31Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
64
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
64