相关实验视频

Updated: Jun 12, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

可穿戴的释放氧化的抗菌插件,用于预防与设备相关的感染

Manjyot Kaur Chug¹, Aasma Sapkota¹, Mark Garren¹

¹School of Chemical, Materials & Biomedical Engineering, University of Georgia, Athens, GA, USA.

Journal of controlled release : official journal of the Controlled Release Society

|September 17, 2024

概括

一种新的便携式抗微生物导管插入器 (PACI) 使用氧化 (NO) 来预防与设备相关的感染. 这种创新的NO释放技术在不伤害人体细胞的情况下显示了90%以上的细菌减少.

科学领域:

生物材料科学生物材料科学
传染性疾病传染性疾病
医疗设备创新医疗设备创新

背景情况:

医疗器械相关的感染是一个重大的医疗保健挑战,通常是由管等内置设备上的细菌生物膜引起的.
现有的预防策略在有效性和长期应用方面存在局限性.
导管上的细菌生物膜会导致严重的感染,包括血液和尿路感染.

研究的目的:

开发和评估一个便携式抗菌导管插入器 (PACI),用于预防医疗器械相关的感染.
利用氧化 (NO),因为它具有强大的抗微生物特性,可以阻止细菌粘附和生物膜形成.
创建一个高效,生物相容和持久的抗感染溶液.

主要方法:

一种光启动的氧化 (NO) 供体S-nitroso-N-acetylpenicillamine (SNAP) 与一个聚二甲基 (PDMS) 聚合物进行了共链接,以提高NO负荷和稳定性.
该SNAP-PDMS材料被集成到侧面发光光纤上,形成一个功能性抗微生物插件,由可穿戴的450nm光模块激活.
通过光催化,评估了插件在24小时以上通过光催化释放治疗NO水平的能力.

主要成果:

开发的PACI证明了持续的氧化 (NO) 释放至少24小时.
从PACI中释放的光催化NO实现了90%以上的细菌活力降低,可以对抗金黄色葡萄球菌,表皮葡萄球菌和神奇蛋白菌.
NO释放对哺乳动物细胞没有细胞毒性作用,证实了生物相容性.

结论:

便携式抗菌导管插入器 (PACI) 有效地防止细菌生物膜的形成,并通过光催化NO释放减少细菌的活力.
SNAP-PDMS材料提供了一个稳定高效的平台,用于持续的NO输送,克服了以前方法的局限性.
这种不释放NO的插件为临床应用提供了一个有希望的,可适应的解决方案,用于对抗导管相关的感染.

关键词:

抗菌插入器抗菌插入器导管消毒导管消毒导管消毒氧化氧化是什么?这是一款便携式的便携式手机.无线无线无线无线无线

更多相关视频

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

相关概念视频

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...