癌症患者患有慢性移植与宿主疾病的症状背后的生物行为机制
Jenna L Hansen1, Meredith E Rumble2, Christopher L Coe3
1Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53719, USA.
Brain, behavior, and immunity
|September 17, 2024
概括
慢性移植对宿主疾病 (cGVHD) 患者会出现与炎症相关的症状. 在cGVHD幸存者中,特定的炎症标志物,而不是昼夜节律,与更严重的抑郁,焦虑,性功能,失眠和疲劳有关.
科学领域:
- 免疫学 免疫学 免疫学
- 生物行为科学 生物行为科学
- 移植医学 移植医学
背景情况:
- 慢性移植与宿主疾病 (cGVHD) 是全源造血细胞移植 (HCT) 后的一个重大并发症,导致大量的发病率和症状负担.
- 了解cGVHD症状的潜在生物行为机制对于开发有效干预措施至关重要.
- 假设炎症和昼夜休息活动节奏有助于cGVHD患者经历的心理和身体症状.
研究的目的:
- 调查炎症生物标志物和昼夜休息活动模式与cGVHD成人患者患者报告结果 (PROs) 之间的关联.
- 确定潜在的生物行为标来管理cGVHD的症状.
主要方法:
- 57名患有cGVHD的成年人参与了这项研究.
- 参与者接受了为期7天的手腕动图监测,以评估休息活动模式.
- 收集血液样本进行细胞因子和化学因子的分析,参与者完成了验证的PRO测量.
主要成果:
- 高水平的互白素-8 (IL-8) 和巨细胞炎症蛋白-1α (MIP-1α) 与抑郁症增加和性功能低下显著相关.
- MIP-1α也与更严重的失眠有关,而单细胞化学吸引蛋白-1 (MCP-1) 与更大的焦虑和疲劳有关.
- 在动图学衍生的休息活动指数和PRO之间发现了很少的关联,尽管以后的活动峰值与性功能较差相关.
结论:
- 涉及cGVHD病变发生的促炎性细胞因子和化学因子似乎对患者经历的症状负担作出了重大贡献.
- 这些炎症生物标志物代表了未来治疗策略的潜在生物行为标,旨在改善cGVHD幸存者的生活质量.
- 循环节律障碍与PROs的相关性有限,这表明炎症在症状表现中起着更为主导的作用.
关键词:
动画摄影是一种动画.焦虑 焦虑是一种焦虑.癌症 癌症 癌症 癌症慢性移植对宿主疾病 慢性移植对宿主疾病抑郁症 抑郁症 抑郁症疲劳 疲劳 疲劳 疲劳 疲劳造血细胞移植 造血细胞移植炎症 炎症是一种炎症.性功能的性功能睡眠 睡眠 睡眠 睡眠更多相关视频
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