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肌肉质量和身体功能在男性艾滋病毒和没有艾滋病毒

Jing Sun¹, Grace L Ditzenberger², Todd T Brown^1,3

¹Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.

The journals of gerontology. Series A, Biological sciences and medical sciences

|September 17, 2024

概括

艾滋病毒感染者 (PWH) 的身体衰退速度更快. 这项研究发现,聚合的骨肌肉密度和面积与更好的身体功能有关,如步行速度和握力,在PWH和没有艾滋病毒的人 (PWoH).

科学领域:

老年学是指老年学的学科.
艾滋病毒/艾滋病研究研究
骨肌肉生理学骨肌肉生理学

背景情况:

与没有艾滋病毒的人 (PWoH) 相比,艾滋病毒感染者 (PWH) 的身体衰退加速,即使有抗逆转录病毒疗法.
骨肌肉健康对于维持身体功能和生活质量至关重要.

研究的目的:

为了比较骨肌肉密度和PWH和PWoH之间的面积.
调查两组骨肌肉特征与身体功能之间的关系.

主要方法:

用L4-L5脊柱区域和大腿的定量计算机断层扫描 (CT) 扫描来评估肌肉群.
探索性因子分析总结了总体的肌肉测量.
多变量线性回归模型与概括估计方程分析了肌肉测量和身体功能 (步行速度,握力) 之间的纵向关联.

主要成果:

两个因素出现了:第1因子代表肌肉密度 (32.5%的差异),第2因子代表肌肉面积 (23.4%的差异).
较高的总体肌肉密度与增加的步行速度 (每单位增加0.028 m/s) 有显著的关联.
总体肌肉密度 (1.88公斤增加) 和面积 (1.60公斤增加) 都与握力增加有关.

结论:

总的骨肌密度和面积测量与PWH和PWoH的身体功能有显著的关联.
这些发现强调了针对骨肌肉健康的干预措施对于促进艾滋病毒感染者或未感染者的健康衰老的重要性.

关键词:

探索性的因素分析.艾滋病病毒艾滋病病毒艾滋病病毒肌肉区域的肌肉区域是什么肌肉密度肌肉密度肌肉密度物理功能物理功能

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