极度早产婴儿神经发育结果的性别差异趋势
Nansi S Boghossian1, Nicole A Mack2, Edward F Bell3
1Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA nboghoss@email.sc.edu.
Archives of disease in childhood. Fetal and neonatal edition
|September 17, 2024
概括
这项研究没有发现男性和女性婴儿在没有神经发育障碍的生存率随着时间的推移而变化的差异. 两性结果都下降了,但两性之间的变化是相似的.
科学领域:
- 新生儿研究新生儿研究
- 儿科神经学 儿科神经学
- 公共卫生 公共卫生
背景情况:
- 早产婴儿面临神经发育障碍 (NDI) 的风险.
- 了解NDI结果中的基于性别的差异对于有针对性的干预至关重要.
- 在NDI结果的时间趋势需要持续调查.
研究的目的:
- 为了确定没有中度或重度神经发育障碍 (NDI) 的生存率的变化是否在1999年至2018年的男婴和女婴之间存在差异.
- 通过婴儿性别分层分析NDI结果的时间趋势.
主要方法:
- 对26307名出生于22-26周妊娠年龄的婴儿进行了回顾性队列研究 (1999-2018).
- 利用了NICHD新生儿研究网络的数据.
- 使用波桑回归来评估没有NDI的生存调整相对风险 (aRR),检查性别和时间之间的相互作用.
主要成果:
- 在1999-2003年和2014-2018年期间,没有NDI的生存率在男性 (32.9%至30.6%) 和女性 (47.4%至40.0%) 两者都下降.
- 与女性相比,男性没有NDI的生存率较低 (aRR=0.80;95%CI 0.78至0.83).
- 在没有NDI的生存时间变化中,没有观察到性别之间的显著差异.
结论:
- 没有中度或重度神经发育障碍的生存率在20多年来,男性和女性早产婴儿的生存率都下降了.
- 尽管男性的总生存率较低,但随着时间的推移,性别之间的变化率并没有显著差异.
- 这些发现表明需要进一步研究影响早产婴儿NDI的性别特异因素.
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