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与CAR T细胞相关的神经毒性:综合性审查

R Ursu1, C Belin1, S Cuzzubbo2

  • 1Service de neurologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Revue neurologique
|September 17, 2024
PubMed
概括

化学抗原受体T细胞 (CAR T细胞) 疗法在治疗癌症方面表现有前途,但可能导致神经系统的副作用. 本综述详细介绍了这些不良事件,其原因和管理策略.

关键词:
脑子 脑子 大脑 脑子用CAR T细胞疗法进行治疗.血液学的恶性瘤.免疫效应细胞相关的神经毒性综合征 (ICANS)神经毒性 神经毒性有毒性 有毒性

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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