器官间沟通参与棕色脂肪组织热生成
Kei Takahashi1, Tetsuya Yamada2, Hideki Katagiri1
1Department of Diabetes, Metabolism and Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Advances in experimental medicine and biology
|September 17, 2024
概括
棕色和色脂肪细胞通过适应性非热生成产生热量. 本综述详细介绍了中央神经系统信号和各种因素如何调节这种对代谢健康至关重要的过程.
科学领域:
- 代谢生理学 代谢生理学
- 脂肪细胞生物学 脂肪细胞生物学
- 热调节 热调节 热调节
背景情况:
- 棕色和色脂肪细胞通过适应性非的热生成产生热量.
- 这个过程对于保持体温和能量平衡至关重要.
- 监管涉及复杂的机关间通信通道.
研究的目的:
- 审查调节棕色和色脂肪细胞热生成的机制.
- 突出中央和外围信号在调节脂肪细胞活动中的作用.
- 探索针对这些途径进行代谢障碍治疗的潜力.
主要方法:
- 审查关于脂肪细胞热生成的现有文献.
- 对幽默和神经元信号通路的分析.
- 确定关键的监管因素及其来源.
主要成果:
- 通过中枢神经系统途径,外围衍生因素 (勒,FGF21) 和神经元信号激活棕色脂肪组织 (BAT) 热生成.
- 其他因素 (格雷林,阿迪波涅丁) 和神经元信号可以抑制BAT热生成.
- 色脂肪细胞受到肌动因,肝动因,心脏因素,感冒和瘦素的刺激.
结论:
- 器官间的沟通显著影响脂肪细胞热生成.
- 了解这些途径是阐明体温调节的关键.
- 准脂肪细胞热生成为代谢障碍提供了新的治疗策略.
关键词:
黄色的脂肪细胞棕色脂肪组织的脂肪组织.葡萄糖酸酶的使用方法机关间的沟通 机构间的沟通勒普丁是一种激素.肝脏 肝脏 肝脏 肝脏过氧体增殖器激活的受体 γ 是什么?塑原激活剂抑制剂-1解蛋白-1-1可以解.阴道神经是什么意思?更多相关视频
04:54Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
Published on: June 2, 2023
1.3K
08:31Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
3.0K
相关概念视频
Body Temperature
918
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
918
Thermoregulation
919
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
919
Hypodermis
4.2K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.2K
