循环时钟和身体温度
Takahito Miyake1, Yuichi Inoue1, Yota Maekawa1
1Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Advances in experimental medicine and biology
|September 17, 2024
概括
身体温度节律对能量平衡至关重要,并由昼夜时钟调节. 分子机制,包括热冲击因子和素受体,同步动物的体温周期.
科学领域:
- 时间生物学 时间生物学
- 生理学 生理学 生理学
- 分子生物学分子生物学
背景情况:
- 循环节律控制着每天的生理周期,身体温度波动是关键输出.
- 这种每天的温度波动 (1-3°C) 会同步外围时钟,并保持能量恒温.
- 热诱导涉及诸如热冲击转录因子和冷诱导型RNA结合蛋白等影响时钟基因表达的因素.
研究的目的:
- 审查昼夜时钟机制与体温调节之间的复杂关系.
- 为了突出涉及跨物种温度调节的保存分子通路.
- 综合当前关于人体温度如何影响和受到昼夜系统影响的知识.
主要方法:
- 关于昼夜节律和体温研究的文献综述.
- 在昼夜时钟中进行热引入的基础分子机制的分析.
- 在不同的动物模型 (poikilotherms,,小鼠) 中对温度调节和时钟基因表达进行比较分析.
主要成果:
- 身体温度表现出稳定的昼夜振荡,这对能量平衡至关重要.
- 特定的分子参与者,包括热冲击转录因子,冷诱导性RNA结合蛋白和托受体,调解热诱导.
- 保存的分子电路,特别是涉及时钟神经元中的素受体,调节和小鼠的体温节律.
结论:
- 身体温度调节和生理节律时钟深深地相互关联,相互影响.
- 了解这些关系是理解生理同步和能量平衡的关键.
- 共同的分子路径强调了昼夜温度调节的进化重要性.
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