整个生命周期中与压力相关的海马和边缘微观结构变化:英国生物银行研究
Elizabeth McManus1, Hamied Haroon2, Niall W Duncan3,4
1School of Health Sciences, The University of Manchester, H.18 Coupland 1 Building, Oxford Rd, Manchester, M13 9PL, UK. elizabeth.mcmanus@manchester.ac.uk.
Scientific reports
|September 17, 2024
概括
儿童时期的压力显著影响大脑的微观结构,特别是在海马和杏仁体,具有持久的影响. 在这项研究中,成年人的压力并没有对大脑结构产生类似的影响.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 医疗成像医学成像
背景情况:
- 高度压力事件可能会导致大脑形态的持久变化.
- 童年是大脑发育的关键时期,使其易受压力影响.
研究的目的:
- 调查童年和成年期压力对灰色物质宏观和微观结构的长期影响.
- 为了检查压力对特定大脑区域的影响,如海马体,杏仁体和丘脑.
主要方法:
- 利用了来自720名英国生物库参与者的T1加权和扩散MRI数据.
- 评估了双边海马体,杏仁体和thalamus中的灰质宏观和微观结构.
- 根据非常高或非常低的童年和成人压力得分分层参与者.
主要成果:
- 儿童时期的压力与海马和杏仁体的双边微观结构变化有关.
- 儿童时期的压力主要影响到海马的双边头部.
- 没有观察到成年期压力或性压力相互作用对大脑微观结构的显著影响.
结论:
- 极度紧张的童年经历对大脑微观结构有持久的影响.
- 这些童年压力影响持续到成年期,无论后来的压力水平如何.
- 单单是成年期的压力并没有对这一队列中大脑微观结构产生显著影响.
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