神经退行,潜在的认知能力和身体活动在健康的衰老中的等离子体标志物
Jonna Nilsson1,2, Yiwen Jiang3, Malin Johannesson4
1Swedish School of Sport and Health Sciences, Stockholm, Sweden. jonna.nilsson@gih.se.
Scientific reports
|September 17, 2024
概括
像神经丝光 (NfL) 这样的血液生物标志物可能反映出健康衰老中的早期大脑变化. 身体活动可能会减轻NfL.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 认知老龄化 认知老龄化
背景情况:
- 针对神经退行症的基于血液的生物标志物显示出对阿尔茨海默氏症的治疗有希望.
- 超敏感的测试可以在健康个体中检测出低度的生物标志物.
- 研究早期的神经退行过程和可修改的危险因素至关重要.
研究的目的:
- 在健康的老年人中探索认知能力和血神经退行性生物标志物之间的关联.
- 检查身体活动对这些生物标志物-认知关系的影响.
- 了解在规范性认知衰老中的早期神经退行变化.
主要方法:
- 对93名健康的老年人 (65-75岁) 的横截面研究.
- 用于评估关系的结构方程建模.
- 测量的血生物标志物:粉样β (Aβ42 / Aβ40比),酸化-tau 181 (p-tau181),状纤维酸蛋白 (GFAP),神经纤维光 (NfL).
- 评估认知能力 (工作记忆,情节性记忆,空间和语言推理) 和身体活动.
主要成果:
- 神经纤维光 (NfL) 与工作记忆负面相关.
- 关于情节性记忆,NfL与中度至强度的体力活动产生相互作用.
- 血生物标志物可以提供对规范性认知衰老的见解.
结论:
- 神经退行性血标志物,特别是NfL,显示出理解认知衰老的潜力.
- 高NfL水平可能表明白质病理,可能限制身体活动对情节性记忆的益处.
- 需要进一步的研究来证实这些发现及其影响.
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