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相关概念视频

Cell-surface Signaling01:21

Cell-surface Signaling

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Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
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Transcriptome Analysis of Single Cells
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细胞聊天 (CellChat) 用于从单细胞转录组学系统分析细胞与细胞之间的通信.

Suoqin Jin1,2, Maksim V Plikus3,4, Qing Nie5,6,7

  • 1School of Mathematics and Statistics, Wuhan University, Wuhan, China. sqjin@whu.edu.cn.

Nature protocols
|September 17, 2024
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概括

CellChat v2是一个计算工具,可以从单细胞转录组数据推断和分析细胞-细胞通信网络. 此更新版本增强了跨不同生物条件的通信分析.

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科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 系统生物学 系统生物学

背景情况:

  • 单细胞测序的进步使得细胞-细胞通信的系统探索成为可能.
  • 将分子相互作用集成到网络分析中仍然是一个挑战.
  • 上一个 CellChat工具促进了细胞-细胞通信网络推断.

研究的目的:

  • 提供CellChat v2的协议,这是分析细胞间通信的最新工具.
  • 能够从单细胞数据中推断和对细胞间通信进行比较分析.
  • 方便识别各种条件的改变通信,信号和细胞群.

主要方法:

  • 使用简化的质量作用模型来信号概率量化.
  • 包括连接体-受体相互作用,多子单元结构和辅因子调制.
  • 使用定量指标和机器学习进行系统的网络分析.

主要成果:

  • CellChat v2提供了增强的比较功能和扩展的联体受体数据库.
  • 包括丰富的功能注释和一个交互式CellChat Explorer.
  • 提供了一个分析单细胞转录组数据的协议,用于细胞通信.

结论:

  • CellChat v2提供了一个用户友好的协议,用于深入的细胞-细胞通信分析.
  • 该工具有助于识别特定于生物条件的通信变化.
  • 可访问的R实现和教程支持在单细胞数据分析中广泛采用.