由于Corynebacterium条形细菌,MRSA和MRSE引起的血液感染的比较
Shu-Hua He1, Yan Chen1, Hong-Li Sun2
1Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing, 100730, China.
BMC infectious diseases
|September 17, 2024
概括
与MRSA和MRSE相比,Corynebacterium striatum血流感染 (BSI) 存在独特的挑战,通常显示延迟检测和更高的死亡率. 早期抗生素治疗对于改善疑似C.striatumBSI的结果至关重要.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 细菌学 细菌学是一门学科.
背景情况:
- 状细菌 (Corynebacterium striatum) 越来越多地被认为是一种导致血液感染 (BSI) 的机会性病原体.
- 这项研究研究了C.striatum BSIs的临床特征和结果.
研究的目的:
- 分析C.striatum血流感染的临床特征和结果.
- 为了比较C.striatum的BSI与污染和其他格拉姆阳性BSI.
主要方法:
- 住院患者的回顾性分析,血液培养中呈阳性C.条纹菌 (2014年1月 - 2022年6月).
- 将它们分为C.striatum-BSI和污染组.
- 与甲素耐药黄金葡萄球菌 (MRSA) -BSI和甲素耐药表皮葡萄球菌 (MRSE) -BSI队列进行比较.
主要成果:
- 与污染 (42.5小时),MRSA (20小时) 和MRSE (19小时) 相比,C.striatum-BSI病例的阳性反应时间较长 (27小时).
- 在24小时内适当的抗生素治疗对C.条纹体-BSI相比MRSA (64.5%) 和MRSE (65.9%) 显着较低 (28%).
- 与MRSA (25.8%) 和MRSE (18.2%) 相比,C.striatum-BSI的28天死亡率 (52.0%) 显著更高.
结论:
- C.striatum-BSI表现出明显的临床特征,包括延迟血培阳性和升高的死亡率.
- 建议对C.striatum-BSI.提前怀疑并给予适当的抗生素.
- 对C.striatum BSIs的最佳管理策略进行进一步的研究是有必要的.
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