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在完全睡眠剥夺和实验性肌肉疼痛后的精神物理变化
Emma Hertel1,2, Elaxmi Sathiyalingam1, Linea Pilgaard1
1Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Journal of sleep research
|September 18, 2024
概括
在健康人群中,将延迟发作的肌肉疼痛 (DOMS) 与完全睡眠剥夺 (TSD) 结合起来,导致疼痛耐受性降低和疼痛调节受损. 这种新型模型突出了睡眠不足如何影响外围和中心疼痛机制.
科学领域:
- 疼痛研究 疼痛研究
- 睡眠科学 睡眠科学
- 人类生理学 人类生理学
背景情况:
- 众所周知,睡眠障碍会使慢性疼痛恶化,增加心理痛苦,并增加炎症.
- 延迟发作的肌肉疼痛 (DOMS) 模式是外周疼痛,而睡眠剥夺会影响中央疼痛机制.
研究的目的:
- 开发一种结合DOMS和总睡眠剥夺 (TSD) 的新型模型,以研究对外围和中心疼痛机制的影响.
- 评估这种综合模型对疼痛敏感性,疼痛调节,炎症和心理因素的影响.
主要方法:
- 30名健康参与者接受了DOMS诱导方案,随后进行了24小时的TSD.
- 评估包括介质素-6 (IL-6) 水平,睡眠质量,疼痛灾难化,影响,焦虑,抑郁症状,压力疼痛值,时间总和和条件疼痛调制 (CPM).
主要成果:
- 在TSD之后,参与者显示疼痛耐受性显著降低,CPM受损.
- 心理测量显示,疼痛减少了灾难性,积极影响,消极影响和焦虑.
- 回归模型表明,基线炎症,心理状态和疼痛敏感性预测了DOMS疼痛强度.
结论:
- 将DOMS与一晚的TSD相结合会引起疼痛过敏,损害内源性疼痛抑制 (CPM),并改变心理状态.
- 这个模型有效地影响了外围和中心疼痛通路,为疼痛慢性化提供了洞察力.
- 基线生理和心理因素在这种联合DOMS和TSD模型中显著预测疼痛强度.
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