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延迟折扣和核 accumbens 功能连接性与 ABCD 研究中的青少年的体重状况有关
L Nate Overholtzer1,2,3, Hedyeh Ahmadi1, Katherine Bottenhorn1
1Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Pediatric obesity
|September 18, 2024
概括
较大的延迟折扣和改变的核连接性与更高的儿童肥胖症有关. 这些因素独立地与早期青少年的体重状况有关,为潜在的肥胖干预提供了信息.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖是一个日益蔓延的流行病,神经风险因素尚不清楚.
- 延迟折扣是奖励估值的衡量标准,与权重地位有不一致的联系.
- 核心积分,大脑的奖励系统的一部分,显示肥胖的变化.
研究的目的:
- 调查体重状况指标,延迟折扣和早期青少年中核 accumbens 功能连接之间的关系.
- 探索导致儿童肥胖个体风险的神经机制.
主要方法:
- 利用了青少年大脑和认知发展 (ABCD) 研究的数据.
- 采用多层纵向线性建模来分析关联.
- 使用身体质量指数Z分数 (BMIz) 和腰与身高比率Z分数 (WHtRz) 评估体重状况.
- 检查核 accumbens 功能连接与各种大脑网络.
主要成果:
- 在3819名参与者中,较高的延迟折扣与增加的BMIz和WHtRz相关.
- 核 accumbens 连接到特定的大脑网络预测了 1817 名参与者的 BMIz.
- 核的功能连接没有调解延迟折扣和BMIz之间的联系.
结论:
- 延迟折扣和核 accumbens 功能连接性独立地与青春期早期的体重状况相关.
- 了解奖励处理和过度饮食行为对于开发有效的肥胖干预措施至关重要.
- 这些发现突出了解决儿童肥胖问题的潜在神经点.
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