在肥胖无症状患者中,高分辨率食道力测定标准值
Khanh Hoang Nicholas Le1, Eric E Low1, Priya Sharma1
1Department of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA.
Neurogastroenterology and motility
|September 18, 2024
概括
大多数患有肥胖症的无症状患者表现出正常的食道计量 (高分辨率计量). 肥胖与更高的胃内压力有关,需要调整规范值以避免误诊.
科学领域:
- 胃肠病学 胃肠病学
- 腹部外科 腹部外科
- 食道生理学 食道生理学
背景情况:
- 腹腔外科手术是有效的,但可能会导致术后食道问题.
- 手术前食道生理对这些风险的影响尚不清楚.
- 肥胖患者的标准食道测量值还没有很好地定义.
研究的目的:
- 在无症状肥胖患者中确定标准的食道高分辨率计量 (HRM) 值.
- 在这个人群中确定食道动力障碍的患病率.
主要方法:
- 对104名无症状成人患者的回顾性研究,BMI≥35kg/m2.
- 患者接受了重症前手术评估,包括HRM.
- 数据是在2019年2月至2020年2月期间在一个单一中心收集的.
主要成果:
- 在90.4%的患者中,食道运动正常.
- 无效的食道运动性,EGJOO,远端食道,和超收缩性食道在10%的患者中被发现.
- 与非肥胖群体相比,观察到较高的LES IRP和DCI值;BMI与胃内压力增加相关.
结论:
- 大多数无症状肥胖患者表现出正常的食道计量.
- 肥胖与较高的LES IRP和DCI以及增加的胃内压力有关.
- 建议对肥胖患者进行调整的规范值,以防止EGJOO和超收缩食道的过度诊断.
相关概念视频
Esophageal Strictures-II: Clinical Features and Management
51
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
51
Barrett Esophagus-II: Clinical Manifestations and Management
121
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
121
Gastroesophageal Reflux Disease II: Clinical Features and Management
57
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
57
Barrett Esophagus-I: Introduction
72
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
72
Esophageal Strictures-I: Introduction
66
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
66
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
291
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
291


