晚期非小细胞肺癌患者在一线治疗期间体重和身体组成的频率增加
Philip Bonomi1, Hita Moudgalya2, Sandra L Gomez3
1Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL, USA.
Journal of cachexia, sarcopenia and muscle
|September 18, 2024
概括
在晚期非小细胞肺癌 (NSCLC) 患者中,无论治疗方式如何,体重增加都涉及肌肉质量和脂肪组织的增加. 这些发现表明,在不同癌症护理标准中,体重变化是相似的.
科学领域:
- 在瘤学瘤学.
- 身体组成分析 身体成分分析
- 癌症 卡切西亚 研究 研究
背景情况:
- 在接受不同治疗标准的高级非小细胞肺癌 (NSCLC) 患者中评估身体成分变化.
- 对目前的护理标准 (CSOC) 和NSCLC的前期护理标准 (FSOC) 的结果进行比较.
研究的目的:
- 确定晚期NSCLC患者体质组成增加的频率.
- 为了研究体重变化和身体组成变化之间的关系.
- 为了比较接受CSOC和FSOC的患者之间的这些变化.
主要方法:
- 对两个队列的分析:CSOC (n=106) 和FSOC (n=88) 晚期NSCLC患者.
- 身体组成 (SMI,SATI,VATI,IMATI) 和体重测量在基线,6周和12周使用CT扫描和临床访问.
- 统计分析以将体重变化与身体组成参数相关联.
主要成果:
- 两个队伍均显示体重,BMI,SMI和SATI的中位数下降,但一个子组经历了增加.
- 类似的百分比的患者 (20.5%和27.3%在12周) 显示体重,BMI,SMI和SATI的增加 (≥2.5%).
- 在体重变化和SMI和SATI变化之间发现了正相关性 (r=0.31-0.58).
结论:
- 尽管中位数下降,但CSOC和FSOC队列中类似比例的患者体重,BMI,SMI和SATI都增加了.
- 晚期NSCLC患者的体重增加与肌肉质量和脂肪组织的增加有关.
- 结果可能会为临床试验设计和癌症缓解症研究提供信息.
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