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Updated: Jun 12, 2025

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[卡纳格利弗洛辛可以通过调节铁亡来改善HFpEF大鼠的心脏功能]

S Ma1, Q J Zuo2, L L He2

  • 1Department of Pain, Hebei General Hospital, Shijiazhuang 050051, China.

Zhonghua xin xue guan bing za zhi
|September 18, 2024
PubMed
概括

卡纳格利弗洛辛治疗通过调节铁亡,一种涉及铁的细胞死亡过程,改善了心力衰竭和保存喷射分数 (HFpEF) 的老鼠的心脏功能.

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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