[关于妊娠期血压与2岁儿童神经发育之间的关联的前性出生队列研究]
1The Institute of Environmental Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
|September 18, 2024
概括
妊娠期血压升高,包括其平均值,累积水平和可变性,与2岁儿童的神经发育得分较低有关. 这种关联强调了监测母亲血压对儿童发育结果的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
背景情况:
- 孕期血压是母亲和胎儿健康的关键指标.
- 早期儿童的神经发育结果受到各种产前因素的影响.
- 了解母亲血压对儿童神经发育的影响对于公共卫生至关重要.
研究的目的:
- 研究2岁儿童妊娠期血压和神经发育指数的各种测量之间的关联.
- 分析怀孕期间血压的平均,累积和变异性与儿童神经发育之间的关系.
- 为了确定与神经发育结果最强烈相关的特定三季度或血压参数.
主要方法:
- 利用了来自"武汉健康婴儿分娩队列"的数据,其中包括3,754对母婴对.
- 血压的计算平均值,累积值和可变性 (SD,CV,VIM) 在整个怀孕期间和每三个月.
- 在2岁时使用心理发展指数 (MDI) 和精神运动发展指数 (PDI) 评估神经发育.
- 采用多变量线性回归和统计分析的概括估计方程.
主要成果:
- 更高的妊娠血压平均值,累积值和变化率 (静脉压,腹压,脉压) 与MDI和PDI得分有负相关性.
- 所有三个月的平均静缩血压与MDI/PDI有负相关性.
- 累积血压和神经发育之间的负面关联主要在第一季度观察到.
- 怀孕期间血压变化与MDI/PDI呈现负面关联,主要是在第二和第三季度.
结论:
- 妊娠期血压参数,包括平均水平和可变性,与2岁儿童的神经发育指数有负相关性.
- 这些发现强调了孕期母亲高血压对认知和精神运动发育的潜在影响.
- 需要进一步的研究来探索潜在的机制和临床影响.
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