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Updated: Jun 12, 2025

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

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[低剂量皮肤组织衍生对 keloid 纤维细胞的功能和原表达的影响]

L Chen1, J Li2, J Y Li3

  • 1Division of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China Department of Plastic & Cosmetic Surgery, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital),Nanjing 210004, China.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
|September 18, 2024
PubMed
概括

过度缩性痕的皮肤可以影响 keloid 纤维细胞的功能. 具体来说,PDHPS5抑制了迁移,并降低了原蛋白 (COL1A2) 和肌纤维细胞 (ACTA2) 蛋白质的表达,为痕治疗提供了潜力.

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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