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Updated: Jun 12, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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由DNMT3B中的ICF综合征相关突变引起的DNA甲基化缺陷的分子机制

Chao-Cheng Cho1, Cheng-Yin Fei1, Bo-Chen Jiang1

  • 1Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC.

Protein science : a publication of the Protein Society
|September 18, 2024
PubMed
概括

在DNA甲基转移酶3B (DNMT3B) 中的突变破坏了它的功能,导致DNA低甲基化和ICF综合征. 这项研究揭示了特定突变如何影响DNMT3B结构,DNA结合和甲基转移酶活性.

关键词:
通过DNA甲基化.晶体结构 晶体结构表观遗传修饰是一种表观遗传修饰.人类疾病 人类疾病

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