口腔白血病的复发:系统性审查和元分析
B P Bhattarai1, A K Singh2, R P Singh3
1Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Journal of dental research
|September 18, 2024
概括
口腔白血病 (OL) 的管理是困难的,因为复发和恶性转变 (MT) 的风险. 激光手术,特别是切除和蒸发,在减少OL复发和随后的MT风险方面表现有前途.
科学领域:
- 口腔医学是指口腔医学.
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 口腔白血病 (OL) 由于高复发率和恶性转变 (MT) 的潜力,存在重大管理挑战.
- 相比于非复发性病变,复发性OL显示MT的风险明显增加.
研究的目的:
- 进行一项元分析,调查OL复发与各种手术技术之间的关联.
- 确定影响OL复发和MT风险的临床病理因素.
主要方法:
- 对EMBASE,PubMed,Scopus和Web of Science进行系统的电子搜索,以寻找有关OL复发术后的研究.
- 对OL复发的聚合比例估计,包括对手术技术和临床病理因素的子组和元回归分析.
- 网络元分析以比较手术方式以尽量减少OL复发.
主要成果:
- 在80项研究 (7,614个样本) 中观察到总的复发比例为22%.
- 基于激光的手术,特别是激光切除和蒸发的组合,与其他方法相比,复发率较低.
- 与更高的复发率相关的因素包括逆口腔/多个部位,非均类型,年龄较大,女性性别,不足的边缘,回顾性数据和贝特尔使用.
结论:
- 激光切除和蒸发的结合可能是减少口腔白血病复发的最佳手术方法.
- 老年患者,女性和非均质病变的口腔白血病需要在手术后进行警监测,因为复发风险增加.
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