怀孕期糖尿病和超重/肥胖妇女的怀孕和产后RCT:PAIGE2研究
Bridie J Kemp1, Bronagh Kelly1, Georgina Cupples1
1Regional Centre for Endocrinology and Diabetes, Royal Jubilee Maternity Centre, Belfast Health and Social Care Trust, Belfast BT12 6BA, UK.
对孕期糖尿病 (GDM) 和超重/肥胖妇女的生活方式干预措施在产后12个月没有显著改善体重减轻. 需要进一步的研究来优化这种干预,以获得更好的结果.
科学领域:
- 生殖医学 生殖医学
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 妊娠期糖尿病 (GDM) 和超重/肥胖症在怀孕和产后期间存在重大风险.
- 有效的生活方式干预对于管理GDM和相关的体重问题至关重要.
- 多组件干预的长期结果需要进一步研究.
研究的目的:
- 评估怀孕和产后多元组件生活方式干预措施的有效性.
- 评估对产后12个月体重,体重指数 (BMI),腰围 (WC) 和空腹血葡萄糖 (FPG) 的影响.
- 为了比较干预组和接受常规产妇护理的对照组之间的结果.
主要方法:
- 一组235名怀孕妇女的GDM和BMI≥25公斤/平方米参与.
- 干预包括教育课程,活动追踪器,电话,励志短信和体重管理支持.
- 体重,BMI,WC和FPG的测量是在分娩后6周,6个月和12个月进行的.
主要成果:
- 干预组的平均体重变化为-2.0公斤,对照组的平均体重变化为-0.6公斤,不显著的差异为-1.4公斤 (P = .34).
- 在二次结果中没有观察到统计学上显著的差异,包括BMI,WC和FPG.
- 这项干预措施并没有导致体重减轻显著改善,与产后12个月的常规护理相比.
结论:
- 测试的多组分生活方式干预措施在产后12个月内没有在患有GDM和超重/肥胖的女性中产生统计学上显著的体重减轻.
- 这些发现表明,目前的干预组件可能需要改进或更好地应用.
- 需要进一步的研究来优化生活方式干预措施,以改善这一群体的产后健康结果.
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