相关实验视频

Updated: May 6, 2026

Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates

Preparation and Analysis of In Vitro Three Dimensional Breast Carcinoma Surrogates

Published on: May 9, 2016

3D生物打印的乳腺癌模型揭示了细胞外基质和辐射敏感度的斯特罗玛介导调制

Theo Desigaux^1,2, Leo Comperat^1,2, Nathalie Dusserre^1,2

¹Univ. Bordeaux, Tissue Bioengineering INSERM U1026, F-33000, Bordeaux, France.

Bioactive materials

|September 18, 2024

概括

这项研究引入了一个3D生物打印的乳腺癌模型,模仿瘤微环境. 该模型准确地复制了瘤的发展和对放射治疗的反应,为药物发现提供了新的工具.

科学领域:

生物医学工程生物医学工程
癌症生物学癌症生物学
在3D生物打印中使用3D生物打印

背景情况:

乳腺癌治疗耐药性是一个重大挑战.
目前的模型缺乏复制瘤微环境动态的复杂性.
了解瘤微环境相互作用对于有效治疗至关重要.

研究的目的:

开发乳腺癌微环境的3D生物打印模型.
研究癌症相关纤维细胞 (CAFs) 在瘤发育和治疗反应中的作用.
建立一个平台来评估新的治疗策略.

主要方法:

微挤出生物打印,以创建不同的癌症和肌肉部.
纳入癌细胞和与癌症相关的纤维细胞 (CAF).
分析瘤微环境成熟,细胞外矩阵重塑和对放射治疗的反应.

主要成果:

生物打印模型显示功能成熟,包括缺氧核心和增加的增殖.
CAFs促进了微血管样结构复杂性和细胞外基质沉积,增加了瘤的硬性.
该模型总结了治疗反应,CAFs通过膜信号保护癌细胞免受放射治疗.

结论:

3D生物打印可以生成复杂的乳腺癌模型,模仿人类病理.
CAFs显著影响瘤发育,纤维化和治疗耐药性.
这种生物打印平台对破译微环境相互作用和测试向药物充满希望.

关键词:

生物打印是一种生物打印技术.癌症微环境癌症微环境细胞外矩阵是细胞外矩阵.

更多相关视频

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

Direct Bioprinting of 3D Multicellular Breast Spheroids onto Endothelial Networks

Direct Bioprinting of 3D Multicellular Breast Spheroids onto Endothelial Networks

Published on: November 2, 2020

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...