一名19岁女性的类固醇依赖性复发性IgA血管炎
Hannah Berrett1, Shivangi Gohil1, Rebecca Kurian1
1Menorah Medical Center, Overland Park, KS.
HCA healthcare journal of medicine
|September 18, 2024
概括
免疫球蛋白A (IgA) 血管炎在成人中可能是严重的. 类固醇节约剂在治疗复发病例方面表现有前途,为皮质类固醇提供了替代品,但长期益处有限.
科学领域:
- 儿科和成人类风湿病学
- 腎臟病學 (nephrology) 是一種醫學.
- 皮肤病学 皮肤病学
背景情况:
- 免疫球蛋白A (IgA) 血管炎是一种常见的儿童疾病,通常是自发的.
- 在成年人中,IgA血管炎往往呈现出严重程度和复发率的增加.
- 这一案例凸显了年轻成年人治疗复发性类固醇依赖性IgA血管炎的挑战.
研究的目的:
- 在一个19岁的女性中呈现一种复发性,依赖于类固醇的IgA血管炎的病例.
- 讨论皮质类固醇治疗在治疗慢性IgA血管炎方面的局限性.
- 探索类固醇节约剂对于耐火性IgA血管炎的潜力.
主要方法:
- 一个19岁的女性病例报告,有童年IgA血管炎的病史.
- 临床表现包括蛋白尿和明显的紫色皮疹.
- 治疗涉及高剂量的静脉注射类固醇,随后逐渐减少和复发.
主要成果:
- 患者在降低类固醇剂量后出现了皮疹的复发.
- 长时间使用类固醇导致高血糖和蛋白尿症恶化.
- 皮质类固醇在实现长期缓解方面表现出有限的有效性.
结论:
- 皮质类固醇对IgA血管炎的长期预后的影响有限.
- 类固醇节约剂是复发性,依赖于类固醇的IgA血管炎的潜在治疗途径.
- 对于成人IgA血管炎的治疗,需要对类固醇节约治疗进行进一步的研究.
相关概念视频
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Gastritis-II: Pathophysiology
273
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
273
Autoimmune Disorders
395
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
395
Gastritis-I: Introduction and Types
291
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
291


