SARS-CoV-2 变种的出现是由与登革热的同时感染引起的
Hassan M Al-Emran1, Fazlur Rahman2, Laxmi Sarkar3
1Department of Biomedical Engineering, Jashore University of Science and Technology, Jashore, Bangladesh.
Bioinformatics and biology insights
|September 18, 2024
概括
与登革热病毒的同时感染显著增加严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 突变,可能导致新变种的出现. 这一发现凸显了产生新型SARS-CoV-2菌株的并发流行病风险.
科学领域:
- 病毒学和分子流行病学.
- 传染病的动态传染病的动态.
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 已经演变为多种关注的变体 (VOCs),具有增加的传染性和严重性.
- 了解推动VOC出现的基因组因素,特别是在共感染场景中,对于公共卫生监测至关重要.
研究的目的:
- 为了调查SARS-CoV-2和登革热病毒联合感染在孟加拉国Jashore的流行情况.
- 分析共同感染对SARS-CoV-2进化和VOC出现的基因组影响.
主要方法:
- 基于医院的COVID-19监测确定了阳性患者;随机选择了一个子集用于联合感染分析.
- 对SARS-CoV-2的全基因组测序是在同时感染和非同时感染的个体上进行的.
- 使用ARIMAX模型和比较基因组分析来评估SARS-CoV-2变种中的氨基酸替代.
主要成果:
- 在572名COVID-19患者中,11名 (2%) 患有登革热病毒共感染.
- 同时感染的SARS-CoV-2患者的氨基酸替代平均数量 (30.6) 与登革热阴性患者 (25.6) 相比显著更高.
- 德尔塔和欧米克朗变种的出现需要比早期的变种 (如阿尔法,贝塔和玛) 更多的氨基酸替代.
结论:
- 与SARS-CoV-2共同感染的登革热病毒与病毒突变的增加率有关.
- 同感染期间受损宿主免疫力可能会提高病原体的适应性,并加速新型SARS-CoV-2变种的出现.
- 同时的流行病对新型和可能更危险的病毒菌株的出现构成重大风险.
相关概念视频
00:57Viral Recombination
23.3K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.3K
00:36Viral Mutations
32.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.2K
01:05Single Nucleotide Polymorphisms-SNPs
14.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.8K
01:20Infection
7.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.7K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K