便转移对肠道微生物群的影响:系统性审查
Shien Wenn Sam1,2, Bilal Hafeez1,2, Hwa Ian Ong1,2
1Faculty of Medical and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
Gut microbiome (Cambridge, England)
|September 18, 2024
概括
便的转移会导致肠道微生物组失调,减少有益的细菌和多样性. 这些变化与转移性结肠炎的严重程度相关,并且可能随着肠道连续性恢复而改善.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 结肠直肠手术 结肠直肠手术
背景情况:
- 便转移可以导致转移性结肠炎 (DC).
- 微生物组失生症与DC的发展和治疗有关.
- 了解转移后的微生物组变化对于临床管理至关重要.
研究的目的:
- 为了描述便转移后的微生物组变化.
- 为了确定这些微生物组变化的临床影响.
- 审查关于转移相关肠道失调的现有文献.
主要方法:
- 在MEDLINE,EMBASE和CENTRAL数据库中的系统文献搜索.
- 包括的研究调查了便转移后微生物组的变化.
- 根据PRISMA指南报告的发现.
主要成果:
- 其中六项研究中有五项报告说,转移结肠中的微生物群多样性显著下降.
- 观察到Bacillota的减少和Pseudomonadota的增加在类层面表明了dysbiosis.
- 减少了有益的乳酸细菌和共生菌,与疾病严重程度相反相关.
结论:
- 便转移与转移的结肠中显著的肠道失调有关.
- 微生物组的变化包括减少多样性,增加潜在的致病细菌和有益物种的丧失.
- 这些变化可能对转化性结肠炎有临床影响,并且在恢复肠道连续性后部分可逆.
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