淋巴性多聚马病毒和默克尔细胞多聚马病毒在感染艾滋病毒或B型肝炎或C型肝炎病毒的患者中
Bahman Abedi Kiasari1, Amir Hossein Alipour1,2, Negar Hemmati3
1Microbiology and Immunology Group, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
New microbes and new infections
|September 18, 2024
概括
这项研究调查了患有慢性病毒感染的个体中人类多元病毒,默克尔细胞多元病毒 (MCV) 和淋巴变性多元病毒 (LPV) 的患病率. 在8.52%的参与者中发现了MCV,特别是在HIV阳性个体中更高,而LPV很少见.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 人类多种病毒,包括淋巴细胞多种病毒 (LPV) 和默克尔细胞多种病毒 (MCV),越来越多地被认为具有致病潜力.
- LPV与中枢神经系统 (CNS) 疾病有关,而MCV与默克尔细胞癌 (MCC) 有关.
- 免疫力受损的个体,特别是患有慢性病毒感染的个体,可能面临患有多重瘤病毒相关疾病的风险更高.
研究的目的:
- 确定LPV和MCV在患有慢性病毒感染的个体中的患病率,如HIV,HBV和HCV.
- 调查这些多种病毒与免疫功能受损状态之间的潜在关联.
- 为了描述检测到的MCV和LPV菌株的遗传多样性.
主要方法:
- 从HIV,HBV和HCVPCR阳性和阴性个体中选340个血清样本,使用PCR检测LPV和MCVDNA.
- 通过DNA测序验证病毒存在和身份.
- 遗传学分析以将检测到的病毒菌株与已知的参考进行比较.
主要成果:
- 在总队列的8.52%中检测到默克尔细胞多瘤病毒 (MCV) DNA,在艾滋病毒阳性个体中观察到的患病率显著更高 (26.4%).
- 淋巴性多瘤病毒 (LPV) 仅在一名艾滋病毒阳性患者中检测到,并且没有发现MCV和LPV的同时感染.
- 遗传学分析证实了MCV菌株与已知的参考基因的遗传相似性,并显示LPV序列与LPV-K38.8具有很高的相同性 (99%).
结论:
- 这项研究提供了关于MCV和LPV在慢性病毒感染的免疫功能低下个体中流行率的关键数据.
- 这些发现表明MCV和免疫状况受损之间存在潜在的关联,需要进一步调查.
- 需要进行全面的研究,才能充分了解这些多种病毒在人类群体中的流行病学,传播和临床意义.
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