牙周病与心血管疾病之间的关联:从成像,观测和遗传数据的见解
Mihir M Sanghvi1,2, Julia Ramírez1,3,4, Sucharitha Chadalavada1,2
1William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
JACC. Advances
|September 18, 2024
概括
牙周病与心脏病指标和冠状动脉疾病 (CAD) 风险增加有关. 这些发现表明,牙疾病的管理可能有助于预防心血管疾病 (CVD).
科学领域:
- 心脏病学 心脏病学
- 牙周病学 牙周病学
- 遗传学 是一个遗传学.
背景情况:
- 牙周病是全球普遍存在的疾病.
- 它越来越被认为是心血管疾病 (CVD) 的潜在危险因素.
研究的目的:
- 调查牙周病与心血管磁共振 (CMR) 影像生物标志物之间的关联.
- 检查牙周病与发生冠状动脉疾病 (CAD) 的风险之间的联系.
主要方法:
- 利用了来自48万多个人的英国生物库数据.
- 采用非侵入性心脏成像 (CMR) 和遗传数据.
- 应用多变量回归和考克斯比例危险模型.
主要成果:
- 牙周病与改变左心室 (LV) 质量:体积比和CMR上的下原生T1值相关.
- 患有牙周病的个体表现出明显更高的风险发展事件CAD.
- 牙周病的遗传风险得分与CAD的几率增加有关.
结论:
- 牙周病与亚临床心脏重塑和发生性心脏病的风险增加有关.
- 这些结果强调了在心血管疾病预防策略中考虑牙周健康的重要性.
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