慢性病发病率由阶段模型和它们之间的同时发生解释
Mikel Arróspide Elgarresta1, Daniela Gerovska1, Myrian Soto-Gordoa2,3
1Computational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, Calle Doctor Begiristain s/n, 20014 San Sebastian, Spain.
iScience
|September 18, 2024
概括
多发病性 (MM) 复杂性是使用动态的,多阶段的发病率-年龄模型揭示的. 这种方法有效地代表了多种慢性疾病患者的疾病进展和风险分层.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 老年学是一门学科.
背景情况:
- 多病性 (MM) 涉及多种慢性疾病的同时发生,在医疗保健中构成重大挑战.
- 了解MM的复杂性和进展对于有效的患者管理和资源分配至关重要.
研究的目的:
- 开发和验证一个动态的,多阶段的发病率-年龄模型来表示多病症的复杂性.
- 在查尔森并发症指数 (CCI) 中分析疾病的相互作用网络和风险分层.
主要方法:
- 在巴斯克卫生系统中为MM患者 (2014-2021) 构建多阶段发病率年龄模型.
- 模拟包括查尔森并发症指数 (CCI) 在内的19种疾病,以分析它们的相互作用网络.
- 发病年龄概况的等级分类,以根据死亡风险对CCI疾病进行分类.
主要成果:
- 多步骤模型,男性8步,女性9步,提供了一个非常适合MM的表现.
- CCI疾病形成了一个复杂的相互作用网络,分为低风险和高风险的死亡病理.
- 中枢神经系统疾病表现出最多的步骤数量,表明模型的复杂性更大.
结论:
- 一个动态的,多阶段的发病年龄模型有效地捕捉了多病症的复杂性.
- 疾病进展和死亡风险可以通过发病年龄概况和集群技术进行分层.
- 中枢神经系统,脏和心脏疾病在多病态模式中代表了更复杂的轨迹.
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