相关实验视频

Updated: Jun 12, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

与健康个体相比,对斑块牛皮患者肠道微生物组变化的研究

Karina Polak^1,2, Tomasz Muszyński^3,4, Aleksandra Frątczak¹

¹Department of Dermatology, Medical University of Silesia, Katowice, Poland.

Postepy dermatologii i alergologii

|September 18, 2024

概括

牛皮患者表现出肠道微生物组的变化,特定的细菌属明显少得多. 调节这些肠道细菌可能为牛皮治疗提供了一个新的治疗策略.

科学领域:

皮肤病学皮肤病学
微生物学微生物学
胃肠病学胃肠病学

背景情况:

牛皮与显著的肠道微生物组变化有关.
了解肠道微生物组在牛皮病进展中的作用至关重要.

研究的目的:

调查肠道微生物组组成对斑块性牛皮症严重性的影响.
为了确定与牛皮相关的特定细菌属.

主要方法:

在20名牛皮患者和20名健康对照组中比较肠道微生物组组成.
使用下一代测序 (NGS) 进行微生物组分析.
对细菌属的丰富性和Firmicutes与Bacteroidetes的比率进行了统计分析.

主要成果:

与对照人群相比,牛皮患者的微生物组形状显著不同.
特定的细菌系在牛皮患者中的中位数丰度明显较低 (p=0.033).
菲尔米库特与巴克特罗伊德的比率没有达到统计学意义,但在牛皮患者中显示出更高水平的趋势.

结论:

肠道微生物组的改变在牛皮病原发生过程中很重要.
针对特定的枯竭细菌属可能是治疗的途径.
基于微生物组的干预可以恢复肠道平衡,减少牛皮炎症.

关键词:

这种疾病叫做dysbiosis.我们的肠道微生物组.牛皮是一种牛皮.

更多相关视频

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...