在被诊断为原发性癌症的患者中,第二种原发性癌症的发生率和模式
Jong Jin Sung1, Ae Ri Ahn1,2,3, Ho Sung Park1,2,3
1Department of Pathology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea.
Oncology letters
|September 18, 2024
概括
癌症幸存者面临患第二种原发性癌症 (SPC) 的风险增加. 乳腺癌和结直肠癌幸存者显示SPC的发病率较高,突出了针对性监测的必要性.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 癌症患者的长期存活增加了患第二种原发性癌症 (SPC) 的可能性.
- SPC给幸存者及其家人带来了重大的心理,社会和经济负担.
研究的目的:
- 评估韩国五种常见原发性癌症的幸存者中第二次原发性癌症 (SPC) 发展的风险和模式.
- 识别具有较高SPC风险的特定癌症类型,并调查部位关系.
主要方法:
- 在2007-2009年期间,对5209名被诊断患有第一个原发性癌症 (胃,结直肠,肺,乳腺,甲状腺) 的患者进行了回顾性队列研究.
- 随访至2017年9月,计算SPC的标准化发病率 (SIR).
- 根据原发性癌症类型分析SPC发病率,并调查癌症部位关系.
主要成果:
- 总体而言,6.2%的患者出现SPC.
- 在乳腺癌 (8.8%) 和结直肠癌 (8.6%) 幸存者中观察到较高的SPC发病率.
- 在结直肠 (1.21) 和乳腺癌 (1.66) 幸存者中发现SPC的SIRs升高.
- 在乳腺癌和甲状腺癌之间,以及结肠直肠癌和胃癌之间确定了重要的部位关系.
结论:
- 癌症幸存者,特别是患有乳腺癌和结直肠癌的人,患SPC的风险增加.
- 了解这些风险和地点关系可以为有针对性的后续策略和SPC早期检测工作提供信息.
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