Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chirality in Nature02:30

Chirality in Nature

13.1K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
13.1K
Prochirality02:05

Prochirality

3.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.8K
Chirality02:25

Chirality

23.5K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
23.5K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

8.7K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
8.7K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

11.3K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
11.3K
Properties of Enantiomers and Optical Activity02:24

Properties of Enantiomers and Optical Activity

16.8K
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
16.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Integrating radical deconstruction of the N-N bond in sulfonyl hydrazones and remote 1,4-amino migration to achieve 1,2-carboimination of unactivated alkenes.

Chemical communications (Cambridge, England)·2026
Same author

Dynamic molecular simulation for CL-20/3,5-MDNP(1-methyl-3,5-dinitropyrazole) co-crystal PBX explosives.

Journal of molecular modeling·2026
Same author

Research Progress on Preparation Technology, Structure Optimization and Properties of 3D-Printed Porous Ceramics.

Materials (Basel, Switzerland)·2026
Same author

Ubiquitination in cardiovascular diseases: From molecular mechanisms to therapeutic targeting.

Ageing research reviews·2026
Same author

Achieving Excellent Nonlinear Optics in α‑Ba<sub>2</sub>Ge<sub>4</sub>S<sub>10</sub> via Flux‑Induced Symmetry Breaking.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Objective sleep efficiency moderates the association between depressive symptoms and experimental heat pain sensitivity in pain-free adults: A cross-sectional study.

Journal of psychosomatic research·2026

相关实验视频

Updated: Jun 12, 2025

A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

2.3K

定向性奇拉性,它的不对称控制,以及计算研究.

Shengzhou Jin1, Yu Wang1, Yao Tang2

  • 1School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.

Research (Washington, D.C.)
|September 18, 2024
PubMed
概括

发现了一种新的定向性模型,其中包括C-sp轴和远程阻断组. 这种模型不同于传统的模型,并使奇拉分子的立体选择性合成成为可能.

更多相关视频

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

9.0K
Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.1K

相关实验视频

Last Updated: Jun 12, 2025

A Micropatterning Assay for Measuring Cell Chirality
08:07

A Micropatterning Assay for Measuring Cell Chirality

Published on: March 11, 2022

2.3K
Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

9.0K
Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

8.1K

科学领域:

  • 立体化学是一种立体化学.
  • 有机化学 有机化学
  • 计算化学计算化学

背景情况:

  • 像Felkin-Ahn和Cram这样的传统模型涉及相邻的性中心和阻断组.
  • 在传统模型中,围绕相邻的C2 - C3轴旋转会产生6个能量障碍.
  • 要解释观察到的立体化学结果,需要对奇拉性有新的理解.

研究的目的:

  • 发现和描述一种新型的性:定向性性.
  • 提出一个新型模型系统的导向性奇拉性不同于现有的模型.
  • 为了证明这个新模型在不对称合成和立体化学控制中的实用性.

主要方法:

  • 进行X射线结构分析,以确认通过空间函数组的方向聚合物稳定.
  • 开发了一种新模型,重点关注合性C-C中心和远程阻断器之间的硬体相互作用.
  • 使用奇拉胺辅助剂来对方向聚合物旋转进行立体选择性控制.
  • 采用Suzuki-Miyaura和Sonogashira交叉合反应进行不对称的合成.
  • 密度函数理论 (DFT) 计算,以确定优化对象和相对能量.

主要成果:

  • 发现了定向性心态,其特点是C-C轴和远程阻断器.
  • 新的模型只涉及三种能量障碍,用于围绕罗式C-C3立体单元旋转.
  • 完全的立体选择性是通过使用奇拉胺辅助剂来实现的.
  • 成功地完成了单个方向聚合物的不对称合成.
  • DFT研究为定向异构体提供了优化的结构和能量配置文件.

结论:

  • 定向性奇拉性在立体化学中提供了一个新的范式,从根本上不同于传统模型.
  • 拟议的模型提供了一个更准确的表现在某些奇拉系统的固态相互作用.
  • 这一发现在化学,生物医学和材料科学中具有潜在的应用,为立体选择性合成开辟了新的途径.