与前列腺癌的-223输液相关的双边神经血管玻璃眼
Chelsea M Viscardi1, Jonathan Y Rho1, Charles R Blake1
1The University of Florida, Department of Ophthalmology, 1600 SW Archer Road, Gainesville, FL, 32608, USA.
American journal of ophthalmology case reports
|September 18, 2024
概括
治疗前列腺癌的-223输液可能会导致新血管玻璃眼,这是一个严重的眼睛疾病. 本报告详细介绍了两个这样的案例,强调了潜在的风险和生物机制.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 转移性前列腺癌的治疗通常涉及-223 (Ra-223).
- Ra-223是一种模仿剂,在骨转移中诱导DNA损伤.
- 从Ra-223的眼睛并发症很少报告.
研究的目的:
- 在输注-223后报告两例新血管玻璃眼 (NVG).
- 调查Ra-223与NVG开发之间的潜在联系.
主要方法:
- 两个患有转移性前列腺癌的患者的病例系列介绍.
- 对患者病史,包括Ra-223周期在内的治疗方案和眼部结果的审查.
- 关于"-223,新血管化,二次角度闭眼镜,新血管眼镜"的文献评论.
主要成果:
- 两位患者在完成六次Ra-223.3循环后都发展出了需要手术干预的新血管玻璃眼.
- 一名患者有疑似青光眼的病史;另一个患者以前没有眼睛问题.
- 在文献审查中,没有发现与Ra-223相关的NVG的先前报告.
结论:
- -223可能通过诸如增加血管透性,脑膜炎和破坏VEGF信号传递等机制导致新血管性玻璃眼.
- Ra-223的模仿性质也可能会影响带网,可能导致眼内压力升高.
- 这一案例系列表明,Ra-223治疗引起的眼部并发症,特别是NVG的生物可信性.
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