特拉马多尔化的奇拉式开关,一种潜在的迷幻药物 - - 过去和未来
Israel Agranat1, Ilaria D'Acquarica2
1Organic Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.
ACS medicinal chemistry letters
|September 18, 2024
概括
特拉马多尔是一种合性阿片类药物,经历了几次合性开关. 这种观点主张开发特定的反体药物,并承认特拉马多尔.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
- 药物开发 药物开发
背景情况:
- 特拉马多尔是一种性阿片类止痛药,最初是作为cis-和trans-racemates的混合物获得专利.
- 随着 (±) -cis-(1RS,2RS) 赛马体的开发,发生了显著的性切换,1980年被批准为Tramal.
- 这种配方比其单个反体更受青,突出了在奇拉药物开发中的早期偏好.
研究的目的:
- 审查特拉马多尔的性史,包括其最初的血质形式和随后的性切换.
- 倡导开发和批准特拉马多尔的特定反体配方,特别是 (+) - cis- ((1R,2R) - 特拉马多尔.
- 提出一个关于特拉马多尔潜在的迷幻特性的新视角,作为解决当前特拉马多尔危机的战略.
主要方法:
- 对特拉马多尔的专利历史和性开关演变的文献评论.
- 对药理学数据进行分析,比较特拉马多尔反体和赛马体.
- 了解特拉马多尔潜在的迷幻效应和治疗应用的概念框架.
主要成果:
- 特拉马多尔的开发涉及多个专利的性开关,从种族混合物转移到特定的反体.
- 在最初的开发阶段, (±) -cis-(1RS,2RS) 赛马体 (Tramal) 在临床上比单个反体更受欢迎.
- 对于连续切换到 (+) -cis-(1R,2R) -tramadol及其盐的连续性切换存在专利,这表明正在对特定反体进行研究.
结论:
- 需要开发和批准基于 (+) -cis-(1R,2R) -tramadol的药物.
- 承认特拉马多尔药物是潜在的迷幻药物可能会提供新的治疗途径.
- 这些策略可能通过先进的性药物开发和新的治疗分类,为不断升级的特拉马多尔危机提供解决方案.
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