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William F Tracy1, Geraint H M Davies2, Lei Jia3

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

ACS medicinal chemistry letters
|September 18, 2024
PubMed
概括

研究人员使用enantioselective方法开发了新的glutarimide类似物,以精确控制由Cereblon (CRBN) 对蛋白质的向降解. 这些新型化合物提供了独特的化学空间,并展示了立体化学如何影响降解选择性.

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