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发现和优化Aryl Piperidinone尿酸作为选择性甲基受体2激活剂

Nicholas R Wurtz1, Pravin S Shirude2, Daniel L Cheney1

  • 1Bristol Myers Squibb, Princeton, New Jersey 08543, United States.

ACS medicinal chemistry letters
|September 18, 2024
PubMed
概括

研究人员发现了强效的阿里尔皮佩里迪氨酸激动剂,向甲基受体2 (FPR2). 这些化合物通过在体内诱导INTERLEUKIN-10 (IL10) 来治疗炎症有望.

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