Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.1K
Gene-Environment Interactions01:20

Gene-Environment Interactions

268
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
268
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

341
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
341
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Inheritance01:25

Inheritance

356
Gregor Mendel's pioneering work on the principles of inheritance fundamentally transformed our understanding of how traits are transmitted from generation to generation. His experiments with pea plants laid the groundwork for the discovery of genes, discrete units within organisms that control heredity.
Each gene exists in pairs, and the combination of these genes from both parents forms an individual's genotype. This genotype is a blueprint of potential traits. Examples of genotype...
356

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Effects of Women's Work on Breastfeeding Outcomes and Time Allocation in Bangladeshi Shodagor Fishing and Trading Communities.

Journal of human lactation : official journal of International Lactation Consultant Association·2026
Same author

Dam-Induced Displacement and Disruption Are Associated With Salivary Cortisol Concentration and Patterns of Diurnal Variation.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Patterns of Chronic Stress in Diurnal Salivary Cortisol Already Predict Epigenetic Age Acceleration in Young Adults in the Cebu Longitudinal Health and Nutrition Survey.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Measuring Dynamic Inflammation Regulation in Low-Resource Settings: Results From a Sample of Adults in the Dominican Republic.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Strong concordance of DNA methylation measures between venous and capillary blood - Implications for human epigenome studies.

iScience·2026
Same author

Epigenetic Age Acceleration Is Associated With HIV Infection Independently of Inflammation.

Open forum infectious diseases·2026

相关实验视频

Updated: Jun 12, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

525

调查IGF轴作为跨代影响的途径.

Haley B Ragsdale1, Aaron A Miller1, Thomas W McDade1,2

  • 1Department of Anthropology, Northwestern University, Evanston, IL, USA.

Journal of developmental origins of health and disease
|September 18, 2024
PubMed
概括

母亲的早期成年期能量储存,而不是早期发育,预测怀孕的胰岛素样生长因子 (IGF) 轴生物标志物和后代胎儿生长. 这表明最近的母亲营养,而不是早期发育,通过IGF轴影响胎儿发育.

关键词:
在IGF轴线上.这是代际的,是代际的.增长的增长增长的增长增长的增长.营养状态 营养状况怀孕 怀孕 怀孕 怀孕 怀孕

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

3.8K

相关实验视频

Last Updated: Jun 12, 2025

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

525
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.6K
Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

3.8K

科学领域:

  • 生殖健康 生殖健康
  • 发展生物学 发展生物学
  • 内分泌学 在内分泌学.

背景情况:

  • 早期的营养和生长显著影响成人代谢和生殖健康,影响后代.
  • 胰岛素样生长因子 (IGF) 轴对生长和新陈代谢至关重要,但其在调解母亲经验与后代产前发育中的作用尚未完全理解.

研究的目的:

  • 研究母亲早期营养状况,能量储存和妊娠胰岛素样生长因子 (IGF) 轴之间的关系.
  • 为了检查母体IGF轴生物标志物如何预测后代胎儿生长.

主要方法:

  • 利用了来自塞布长度健康和营养调查 (n=36) 的数据.
  • 分析了2岁,8岁和22岁的母亲体重增加,以及22岁的瘦素 (能量储存).
  • 评估了无IGF-1和IGF结合蛋白3 (IGFBP-3) 的怀孕情况,以及它们与后代出生体重和皮厚度的相关性.

主要成果:

  • 母亲年龄,平价和年轻成年人瘦素水平与怀孕无IGF-1相关,后代出生体重和皮厚度.
  • 怀孕期间的IGF-1水平与成年早期的营养状况比与成年前的发育营养关系更强.
  • 年轻的成年人丁水平显著影响后代的胎儿脂肪质量沉积.

结论:

  • 孕产妇早期成年期的能量状况,由素反映,是妊娠IGF轴功能和后代胎儿生长的关键预测因素.
  • 在预测胎儿发育方面,IGF轴似乎反映了母亲最近的能量状态,而不是长期的发育营养.
  • 不涉及母体IGF轴的替代途径可能会调解先前观察到的母体发育营养和后代出生大小之间的联系.