晚年抑郁症中的焦虑与多个认知领域的表现较差有关
Maria Kryza-Lacombe1,2, Michelle T Kassel1,2, Philip S Insel2
1Mental Illness Research Education and Clinical Centers, Veterans Affairs Medical Center, San Francisco, CA, USA.
Journal of the International Neuropsychological Society : JINS
|September 18, 2024
概括
与焦虑相关的晚年抑郁症会损害诸如记忆和执行功能之类的认知功能. 老年人的这种认知衰退模式反映了神经退行性疾病的特征.
科学领域:
- 老年精神病学是一门精神病学专业.
- 神经心理学 神经心理学
- 认知神经科学 认知神经科学
背景情况:
- 焦虑经常与晚年抑郁症 (LLD) 一起发生.
- 在LLD中伴随性焦虑与全球认知功能恶化有关,独立于抑郁症的严重程度.
- 在LLD中,与伴随性焦虑相关的特定认知领域缺陷仍然不清楚.
研究的目的:
- 研究具有LLD的老年人的特定领域认知功能差异.
- 为了比较具有并发性焦虑症和没有并发性焦虑症的LLD患者之间的认知表现.
- 为了识别与LLD相关的共同疾病焦虑相关的独特的神经心理特征.
主要方法:
- 研究包括228名被诊断患有严重抑郁症的老年人 (65-91岁).
- 参与者进行了焦虑和抑郁症严重程度的评估,并进行了全面的认知功能测试.
- 普通最小平方回归,控制年龄,性别,教育和抑郁症严重程度,分析了群体差异.
主要成果:
- 伴随性焦虑的LLD患者在对抗命名和视觉空间功能方面表现明显较低.
- 语言流利性,工作记忆和抑制也在LLD与伴随性焦虑组中受到损害.
- 即使控制了抑郁症严重程度后,也观察到这些赤字.
结论:
- 伴随性焦虑LLD的认知表现模式与神经退行性疾病中观察到的类似.
- 研究结果表明,这对理解LLD认知障碍的病因有意义.
- 在LLD中的神经心理形状可能会受到伴随性焦虑的存在的影响.
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