在血压调节中与环境暴露的多基因相互作用:HUNT研究
Karsten Øvretveit1, Emma M L Ingeström2, Michail Spitieris1,3
1HUNT Center for Molecular and Clinical Epidemiology (MCE), Department of Public Health and Nursing Norwegian University of Science and Technology (NTNU) Trondheim Norway.
Journal of the American Heart Association
|September 18, 2024
概括
对高血压 (BP) 的遗传倾向可能会增加对环境因素的脆弱性,但这些风险是可修改的. 基因与环境的相互作用突出了个性化高血压预防和管理的潜力.
科学领域:
- 遗传学和环境健康
- 心血管疾病研究研究
- 公共卫生基因组学
背景情况:
- 基本高血压是由复杂的遗传和环境相互作用引起的.
- 既定的生活方式因素 (肥胖,酒精,烟草,饮食,活动) 影响血压 (BP).
- 对BP特征的多基因风险评分 (PRS) 显示出显著的表型变异,但基因与环境的相互作用仍然不清楚.
研究的目的:
- 通过全基因多基因风险评分 (PRS) 和广泛的环境暴露,研究高血压中的基因环境相互作用.
- 为了确定特定的生活方式和生物标志物相互作用与遗传倾向缩和腹血压的遗传倾向.
主要方法:
- 利用了来自HUNT研究 (49,234名参与者) 的基因型和表型数据.
- 模拟了全基因PRS之间的基因与环境相互作用,用于静缩BP (SBP) 和静缩BP (DBP) 和125环境暴露.
- 评估环境因素与SBP和DBP的独立关联,并确定了显著的基因环境相互作用 (P < 2x10^-4).
主要成果:
- 108个与SBP独立相关的环境暴露;100个与DBP相关.
- 确定了SBP-PRS的12个显著的基因环境相互作用和DBP-PRS的4个.
- 发现了心肺呼吸能力,饮食,烟草使用,血清胆固醇,肌素和性酸酶对血压的基因依赖性影响.
结论:
- 遗传敏感的个体可能更容易受到高血压的获得风险因素的影响,但这些影响是可以修改的.
- 基因与环境的相互作用表明,将遗传数据与生活方式评估相结合,可以改善高血压风险分层.
- 基因环境知情风险建模为增强高血压预防和管理策略提供了潜力.
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