叶酸,同型半氨酸和缺血性中风后的不良结果
Mengyao Shi1, Jin Zheng2, Yang Liu2,3
1Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College of Soochow University Suzhou China.
Journal of the American Heart Association
|September 18, 2024
概括
高叶酸水平与缺血性中风后更好的结果有关. 叶酸可以通过降低同类氨酸水平来改善中风预后,从而降低死亡和残疾的风险.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 同类氨酸是心血管疾病的危险因素.
- 叶酸有效地降低了同型半氨酸水平.
- 叶酸,同型半氨酸和缺血性中风预后之间的关系尚不清楚.
研究的目的:
- 为了研究血清叶酸和同类半氨酸水平与缺血性中风的预后之间的关联.
- 为了确定同类氨酸是否调解叶酸对中风结果的影响.
主要方法:
- 对3530名缺血性中风患者进行前性研究.
- 在入院时测量血清叶酸和同类半氨酸水平.
- 在3个月后评估复合结果 (死亡或重大残疾).
- 使用单变量和多变量逻辑回归和调解分析.
主要成果:
- 较高的叶酸水平与死亡和重大残疾风险降低有关.
- 较高的homocysteine水平与死亡和严重残疾的风险增加有关.
- 在叶酸和中风结局之间的关联中,同型半氨酸调解了25.5%.
结论:
- 血清叶酸水平升高与中国缺血性中风患者的预后良好有关.
- 叶酸对中风结果的有益影响部分是由其对同类半氨酸水平的影响来介导的.
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